Protein Details: Potassium voltage-gated channel subfamily B member 2

Function

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes; primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane; letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone; such as KCNS1 and KCNS2; creating a functionally diverse range of channel complexes. In vivo; membranes probably contain a mixture of heteromeric potassium channel complexes; making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells

Sequence

PDB Structures

Ligand Binding